The results of several previous association studies between the SCARB1 rs5888 SNP and atherosclerosis related diseases are not entirely consistent in different ethnic groups (Table 5). Ritsch et al. [26] showed that the T allele of rs5888 SNP was associated with decreased risk of peripheral arterial disease in Austrians. The T allele carriers of the SCARB1 rs5888 SNP in Tunisan reduced the risk of coronary stenosis and increased serum HDL-C levels [27]. Recently I need to order isotretinoin without presciption and order it COD the TT genotype of the SCARB1 rs5888 SNP in male Lithuanian aged 65-75 was also shown to decrease the risk of CAD and increase serum HDL-C levels [28]. Two other studies in Korean and Spanish [24,25] did not report the genotype frequencies, but they also showed that the T allele or the T allele carrier was associated with decreased CAD risk. In the present study, however, we showed that the frequency of TT genotype was higher in CAD patients than in controls. The TT genotype was associated with increased risk of CAD than the CC or CC/CT genotype. The TT genotype was also associated with decreased serum HDL-C levels in the total population. Meta-analysis including three previous association studies showed that the TT genotype was associated with decreased risk of CAD. The reasons for the conflicting results between our and previous studies are not well known. One of the possible explanations was different genetic background. According to the data of the International HapMap project, the allelic frequencies of the SCARB1 rs5888 SNP in diverse racial/ethnic groups are different. The frequencies of C and T alleles were 47.4% and 52.6% in CEU (Utah residents with ancestry from northern and western Europe), 88.1% and 11.9% in YRI (Yoruba in Ibadan, Nigeria), 80.7% and 19.3% in JPT (Japanese in Tokyo, Japan), 75.6% and 24.4% in CHB (Han Chinese in Beijing, China). In addition, the C-T change at exon 8 did not affect its amino acid sequence of the protein. Therefore, the rs5888 SNP might be in linkage disequilibrium (LD) with a functional mutation in the SCARB1 gene, and the LD pattern at this region is different among populations. Accordingly, it is necessary to further study on the associations of the SCARB1 rs5888 SNP and atherosclerosis related diseases in different ethnic populations.. Patients' progress is summarized in Figure 2. The Basal and operative characteristics were almost identical between the two groups (Table 1)..
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